The SystemJ approach to system-level design

In this paper, we propose a new system-level design language, called SystemJ. It extends Java with synchronous reactive features present in Esterel and asynchronous constructs suitable for modelling globally asynchronous locally synchronous systems. The strength of SystemJ comes from its ability to offer the data processing and encapsulation elegance of Java, Esterel-like reactivity and synchrony, and the asynchronous de-coupling of CSP all within the Java framework. Using standard Java environments, for specification and modelling, or specialised reactive embedded processors, for high performance implementation, the SystemJ design flow is extremely versatile. With the increasing attention that Java gets in embedded systems, SystemJ comes to address data and control, software and hardware, modelling and implementation in a unified manner

Primena can bus mreža na traktorima i radnim mašinama

Numerous computer control units have long been an integral part of the tractors and other agricultural machines, making them more efficient and safer. This important technological innovations, CAN Bus network or “Controler Area Network” that allows computer units and their components within the tractor and the other working machines connected, and to thereby provide a reliable and secure communications, and reduce the amount of electrical conductors that would otherwise used for this purpose. Information collected various sensors inside the tractor and the other working machines, CAN Bus network transmits to the computer unit, while establishing priorities among the data, so I arrived for each of them, based on pre-prescribed procedures and protocols, the corresponding response rate was prepared by computer.Različiti tipovi i modeli računarskih upravljačkih jedinica već duži period su sastavni delovi traktora i ostalih poljoprivrednih ili radnih mašina, čineći ih efikasnijim i bezbednijim. Ova veoma važna tehnološka inovacija, CAN Bus mreža ili „Controler Area Network“ omogućava da se računarske jedinice i njihove komponente unutar traktora i drugih radnih mašina povežu u funkcionalnu kompleksnu celinu. Pri tome je obezbeđena pouzdana i sigurna komunikaciju, a smanjena količina električnih provodnika koji bi se inače zbog povezivanja delova sistema koristili. Informacije koje prikupljaju različiti senzori unutar traktora i drugih radnih mašina, CAN Bus mreža prenosi do računarske jedinice, a pri tome uspostavlja prioritete među pristiglim podacima kako bih za svaki od njih, na osnovu unapred propisanih protokola i procedura, odgovarajućom brzinom bio pripremljen odgovor od strane odgovarajuće računarske jedinice

Dizajn, klasifikacija, perspektiva i moguća aplikacija dronova u poljoprivredu Srbije

The paper analyzes the possibility and the needs for the use of specific types of robots (mini unmanned aircraft with different designs and the designation of UAVs) and the possibility of using in agriculture (agrodrone). The year 2015 was proclaimed (Fortune Magazine, 2016) as the year of increasing and widespread use of UAVs in various areas of human activity, especially in agriculture and forestry (75% of use). This is important for large farm areas, where UAV has many useful functions and a very cost-effective commercial application. Today, the needs for UAVs have increased sharply with various opportunities for both civilian and military needs. There is also a significant interest in the development of new drones that can autonomously fly in different environments and locations and can perform various missions and tasks. Over the past decade, a wide range of applications for drones has gained the significance that led to the discovery of various types of unmanned UAVs of different sizes and weights. In this review, the classification of UAVs ranging based on a detailed overview of the development of the drone industry in recent years, this paper demonstrates the evolution of drones and differents application technologies. Of course, this development is very advanced and revolutionary, as well as the development of mobile and smart phones and the Internet, which will open the way for many users to participate in defining the future of UAV implementation. LIVONA Company, Belgrade, Serbia (and Institute of Agricultural Engineering, Faculty of Agriculture in Belgrade, in tehnical cooperation) has a study and plans on the implementation of the model micro drone EBee SQ Livona RTK in the future general plans for inspection of protection Soils of territory Minicipality of Stara Pazova (351 km2), and agricultural company Napredak , and exspecially plans for soils of agriculture of R. Serbia. VEKOM GeoCompany from Belgrade, (in cooperation with Institute of Agricultural Engineering, Faculty of Agriculture in Belgrade), has a study and plans on the implementation of the model of the drone Aibot KX6 model, in the future of application of agricultural soils of region Open pit Kolubara for area from app. 600 km2 and the other soils of Region). Institute of Agricultural Engineering, Faculty of Agriculture in Belgrade, in cooperation with Municipality of Ub, has a study and plans on the implementation of the model micro drone Hubsan H109S X4 PRO in the future plans general inspection of protection Soils and Waters of territory of Municipality Ub (456 km2).U radu su analizirane mogućnosti i potrebe upotrebe specifičnih vrsta robota (mini bespilotnih letelica sa različitim dizajnom, označane kao UAV) i način korištenja u poljoprivredi (agrodron). Časopis Fortune je 2015.godinu proglasio kao godinu sve većeg i široko rasprostranjene upotrbe UAV letelica, u različitim oblastima ljudske delatnosti, posebno u poljoprivredi i šumarstvu (75% upotrebe). Ovo je naročito važno za velike farme i oblasti pod šumama, gde UAV ima mnogo korisnih funkcija i veoma isplative komercijalne aplikacije. Danas, potrebe za UAV imaju nagli porast sa različitim mogućnostima kako za civilne tako i za vojne potrebe. Takođe postoji značajan interes za razvoj novih bespilotnih letelica koji mogu autonomno leteti u različitim okruženjima i lokacijama i obaviti različite misije i zadatke. Tokom protekle decenije XXI veka, širok spektar aplikacija za bespilotne letelice je dobio značaj koji je doveo do konstrukcija različitih tipova bespilotnih UAV, različitih veličina i težina i svakako namene. Naravno, tehnološki razvoj kod dron sistema je veoma tehničko-tehnološki napredan i revolucionaran, uz razvoj mobilnih i pametnih (android) telefona i interneta, brzo otvora puteve i mogućnosti za mnoge korisnike u definisanju nove budućnosti implementacije UAV u različitim oblastima primene . Kompanija Livona d.o.o., Beograd i Institut za poljoprivrednu tehniku, Poljoprivredni fakultet u Beogradu, u tehničkoj saradnji imaju planove o implementaciji modela mikro drona EBee SK Livona RTK u narednim generalnim planovima za inspekciju, zaštitu i korišćenje poljoprivrednih zemljišta Republike Srbije, i posebno teritorije Opštine Stara Pazova (351 km2), gde je posebno mesto poljoprivrednog preduzeća Napredak a.d. VekomGeo d.o.o, Beograd u saradnji sa Institutom za poljoprivrednu tehniku Poljoprivrednog fakulteta u Beogradu ima planove o budućoj upotrebi drona model Aibot X6, za nadzor na površinama od 600 km2 (i poljoprivredna zemljišta) otvorenog kopa R.B. Kolubara ili drugih objekata. Institut za poljoprivrednu tehniku, Poljoprivredni fakultet u Beogradu, ima planove o saradnji sa opštinom Ub, zbog upotrebe modela mikro drona Hubsan H109S Ks4 PRO u inspekciji oko zaštite i načina korišćenja zemljišta i voda na ovoj teritoriji (456 km2)

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

The Influence of Different Types of Physical Activity on The Redox Status of Scuba Divers

The effect of scuba diving on ROS production and oxidative stress compared to that of other recreational activities is still poorly understood. The aim of this study was to assess the influence of different types of physical activity on the redox status of scuba divers by testing the pro- and anti-oxidative parameters immediately before and after different types of physical load. The prevalence study included 10 professional police divers. All examinees were male, 32 ± 5.1 years of age, well-trained, and with a minimum of five to a maximum of 20 years of diving experience. The study was divided into three experimental protocols: 1) an exercise test (at atmospheric pressure), 2) an at sea dive (30 meters for 30 minutes), and 3) a dive into river current (10 meters for 30 minutes). Immediately before and after the load test of the divers at atmospheric pressure and immediately before and after the dive, blood samples were taken to determine the values of the following pro-oxidant markers: O2−, H2O2, NO2− and TBARS, as well as antioxidant enzymes (SOD and CAT). A comparison of the results before and after physical activity for all three protocols revealed a significant increase in values for NO2−, O2−, H2O2 and CAT after physical activity. It can be concluded that the values of all oxidative stress markers depend on the season of the year in which the research is conducted or on the frequency of dives and degree of physical exertion during this period of the year

Тhe Impact Of Positive Acceleration (+Gz) on Antioxidant Capacity and Histopathological Alterations in Different Organs and Tissues in Rats

Since the early 1940s, a significant amount of research has been conducted to describe the impact of the high-G acceleration on the cardiovascular system. The objective of the present study was to examine the role of the antioxidant enzyme system under biodynamic stress in the liver, heart and gastric mucosa in response to high-magnitude +Gz exposure in a rat model. Twenty adult male Wistar albino rats (10 rats per group; 9-11 weeks old, 200-250 g b.w.) were divided into the following two groups: control and G (exposed to a biodynamic stress model under positive (+7 Gz) acceleration for 40 s). The influence of acute biodynamic stress on pro-oxidative parameters in the rat liver (xanthine oxidase (XOD), catalase (CAT), peroxidase (Px), glutathione peroxidase (GSH-Px), total content of glutathione (GSH), lipid peroxidation (LPx)) and on histopathological alterations in the liver, cardiac muscle and gastric mucosa was examined. Biodynamic stress resulting from positive (+7 Gz) acceleration resulted in a highly statistically signifi cant increase of CAT GSH-Px activity compared to the control group. The LPx levels were significantly decreased, but the GSH contents and the activities of other enzymes were not significantly changed. Significant microscopic changes in the liver, heart and gastric mucosa were observed in the G group. These results clearly indicate that +Gz acceleration alters biochemical systems. These alterations in cellular processes may be mediated by influences of hypoxia or ischaemia via changes in the antioxidant capacity

Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis

Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC

Clinicopathological characteristics and survival in Serbian patients with renal cell carcinoma: a retrospective analysis

Purpose: Indications of kidney cancer outcome in lower-income countries are based on an incidence/mortality ratio due to lack of survival information. This study was conducted to provide outcome data in Serbian patients with renal cell carcinoma (RCC) and to identify prognostic factors that could affect their overall survival (OS). Methods: This retrospective study included 185 patients who underwent nephrectomy. We assessed certain clinicopathological data including age, gender, tumor size, grade, stage and histological subtypes for their possible impact on OS. Results: The 5-year OS was 63.2%. Significant association was found between OS and age (log-rank 12.455, p=0.006), tumor size (log-rank 26.425, p=0.000), grade (log-rank 13.249, p=0.000) and stage (log-rank 43.235, p=0.000). Univariate analysis indicated size (p=0.000), grade (p=0.001) and stage (p=0.000) as prognostic factors for OS. In multivariate analysis, grade (p=0.014) and stage (p=0.000) remained significant predictors of OS. Conclusion: Tumor grade and stage were identified as independent prognostic factors of OS survival in Serbian patients with RCC

Stereospecific ligands and their complexes. Part XXI. Synthesis, characterization, circular dichroism and antimicrobial activity of cobalt(III) complexes with some edda-type of ligands. Crystal structure of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N -di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O

The octahedral cobalt(III) complexes with (S,S)-ethylenediamine-N,N-di-2-propionic (S,S-eddp) and (S,S)-ethylenediamine-N,N-di-2-(3-methyl)-butanoic (S,S-eddv) acids and oxalato and malonato ligands, as additional bidentate ligands, were prepared and characterized. The complexes were purified by ionexchange chromatography. The geometry of the complexes has been supposed on the basis of the infrared, electronic absorption and NMR spectra. The A absolute configurations of the isolated complexes have been predicted on the basis of their circular dichroism (CD) spectra and it was confirmed by single-crystal X-ray analysis of potassium-Delta-(-)(589)-s-cis-oxalato-(S,S)-ethylenediamine-N,N-di-(2-propanoato)-cobaltate(III)-semihydrate, K-Delta-(-)(589)-s-cis-[Co(S,S-eddp)(ox)]center dot 0.5H(2)O. Antimicrobial activity of ligands and obtained cobalt(III) complexes was evaluated by determining the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) in relation to 13 species of microorganisms (five strains of pathogenic bacteria, five species pathogenic fungi and three species of probiotic). Tested ligands and complexes demonstrated moderate and low antibacterial and antifungal activity. There was no difference in activities between the ligands and complexes. (C) 2014 Elsevier Ltd. All rights reserved

Dugong grazing and turtle cropping: grazing optimization\ud in tropical seagrass systems?

Grazing by dugongs and cropping by green turtles have the capacity to alter the subsequent nutritional quality of seagrass regrowth. We examined the effects of simulated light and intensive grazing by dugongs and cropping by turtles on eight nutritionally relevant measures of seagrass chemical composition over two regrowth periods (short-term, 1–4 months; longterm, 11–13 months) at two seagrass communities (a mixed species community with Zostera capricorni, Halophila ovalis, Halodule uninervis, Cymodocea rotundata and C. serrulate; and a monospecific bed of Halodule uninervis) in tropical Queensland, Australia. The concentrations of organic matter, total nitrogen, total water-soluble carbohydrates, total starch, neutral detergent fiber, acid detergent fiber, acid lignin, as well as the in vitro dry matter digestibility (IVDMD) were measured in the leaves and below-ground parts of each\ud species using near-infrared reflectance spectroscopy\ud (NIRS). Regrowth of preferred species such as H. ovalis\ud and H. uninervis from simulated intensive dugong grazing after a year exhibited increased (by 35 and 25%, respectively, relative to controls) whole-plant N concentrations. Similarly, regrowth of H. ovalis from\ud simulated turtle cropping showed an increase in the\ud leaf N concentration of 30% after a year. However, these gains are tempered by reductions in starch concentrations\ud and increases in fiber. In the short-term, the N concentrations increased while the fiber concentrations\ud decreased. These data provide experimental support for a grazing optimization view of herbivory in the tropical seagrass system, but with feedback in a different manner. Furthermore, we suggest that in areas where grazing is the only major source of natural disturbance, it is likely that there are potential ecosystem level effects if and when numbers of dugongs and turtles are reduced